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In press

Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S (in press) DNA methylation signatures of early childhood malnutrition associated with impairments in attention and cognition. Biol Psychiatry

Champagne FA & Curley JP (in press). Plasticity of the maternal brain across the lifespan. In HJV Rutherford & LC Mayes (Eds.), Maternal brain plasticity: Preclinical and human research and implications for intervention. New Directions for Child and Adolescent Development


Donaldson ZR, le Francois B, Santos TL, Almli LM, Boldrini M, Champagne FA, Arango V, Mann JJ, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R, 2016, The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry 6:e746.

Curley JP, Champagne FA, 2016, Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods. Frontiers in Neuroendocrinology 40:52-66.

Rubenstein DR, Skolnik H, Berrio A, Champagne FA, Phelps S, Solomon J, 2016, Sex-specific fitness effects of unpredictable early life conditions are associated with DNA methylation in the avian glucocorticoid receptor. Molecular Ecology 25(8):1714-28.

Monk C, Feng T, Lee S, Krupska I, Champagne FA, Tycko B, 2016, Distress during pregnancy: Epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior. Am J Psychiatry 173(7):705-13.

Miller RL, Yana Z, Mahera C, Zhanga H, Gudsnuk K, McDonalde J, Champagne FA, 2016, Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression, and DNA methylation of the Bdnf gene. Neuroepigenetics 5: 11-18.

Stolzenberg D & Champagne FA, 2016, Non-hormonal bases of maternal behavior: The role of experience and epigenetic mechanisms. Hormones & Behavior 77:204-10.

Champagne FA & Isles AR, 2016, Editorial overview: Development and behavior. Current Opinion in Behavioral Sciences 7:iv–vi.


Tost H, Champagne FA, Meyer-Lindenberg A, 2015, Environmental influence in the brain, human welfare and mental health. Nature Neuroscience 18(10):1421-31.

Brunelli SA, Curley JP, Gudsnuk K, Champagne FA, Myers MM, Hofer MA, Welch MG, 2015, Variations in maternal behavior in rats selected for infant ultrasonic vocalization in isolation. Hormones & Behavior 75:78-83.

Jensen Peña C, Champagne FA, 2015, Neonatal over-expression of estrogen receptor-a alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. Developmental Neurobiology 75(10):1114-24.

Franks B, Champagne FA, & Curley JP, 2015, Postnatal maternal care predicts divergent weaning strategies and the development of social behavior. Developmental Psychobiology 57(7):809-17.

Champagne FA, Curley JP, 2015, Epigenetic effects of parental care within and across generations. In: The Family Emotional System: An Integrative Concept for Theory, Science and Practice. Lexington Books.

Braithwaite EC, Kundakovic M, Ramchandani PG, Murphy SE, Champagne FA, 2015, Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation. Epigenetics 10(5), 408-17.

Kundakovic M, Champagne FA, 2015, Early-Life Experience, Epigenetics, and the Developing Brain. Neuropsychopharmacology 40(1), 141-53.

Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA, 2015, DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A 112(22), 6807-13.


Braun K, Champagne FA, 2014, Paternal influences on offspring development: behavioural and epigenetic pathways. J Neuroendocrinology 26(10), 697-706.

Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, McDonald JD, Yan B, Schwartz GJ, Miller RL, 2014, Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) Methylation in Offspring, Grand-Offspring Mice. PLoS One 9(10), e110706.

Tang G, Gudsnuk K, Kuo SH, Cotrina M, Rosoklija G, Sosunov A, Sonders M, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne FA, Dwork A, Goldman J, Sulzer D, 2014, Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 83(5), 1131-43.

Franks B, Champagne FA, Higgins ET, 2014, How enrichment affects exploration trade-offs in rats: Implications for welfare and well-being. PLoS One 8(12), e83578.

Franks B, Higgins EY, Champagne FA, 2014, A theoretically based model of rat personality with implications for welfare. PLoS One 9(4), e95135.

Peña CJ, Neugut YD, Calarco CA, Champagne FA, 2014, Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring. European Journal of Neuroscience 39(6), 946-56.

Donaldson ZR, Piel DA, Santos TL, Richardson-Jones J, Leonardo ED, Beck SG, Champagne FA, Hen R, 2014, Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social behavior. Neuropsychopharmacology 39(2), 291-302.

Mashoodh R, Champagne FA, 2014, Paternal Transgenerational Inheritance. In Transgenerational Epigenetics: Evidence and Debate, Tollefsbol T, ed., Academic Press.

Champagne FA, 2014, The Epigenetics of Mammalian Parenting. In Ancestral Landscapes in Human Evolution: Culture, Childrearing and Social Wellbeing, Narvaez D, Valentino K, Fuentes A, McKenna JJ, Gray P, eds., Oxford University Press.


Branchi I, Curley JP, D’Andrea I, Cirulli F, Champagne FA, Alleva E, 2013, Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels. Psychoneuroendocrinology 38(4):522-32.

Champagne FA, 2013, Early environments, glucocorticoid receptors, and behavioral epigenetics. Behavioral Neuroscience 127(5), 628-636.

Champagne FA, 2013, Effects of stress across generations: Why sex matters. Biological Psychiatry 73(1):2-4.

Champagne FA, 2013, Epigenetics and developmental plasticity across species. Developmental Psychobiology 55(1), 33-41.

Karatsoreos IN, Thaler JP, Borgland SL, Champagne FA, Hurd YL, Hill MN, 2013, Food for thought: hormonal, experiential, and neural influences on feeding and obesity. Journal of Neuroscience 33(45), 17610-6.

Kundakovic M, Gudsnuk K, Franks B, Madrid J, Miller RL, Perera FP, Champagne FA, 2013, Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. Proceedings of the National Academy of Sciences 110(24):9956-61.

Kundakovic M, Lim S, Gudsnuk K, Champagne FA, 2013, Sex-specific and strain-dependent effects of early life adversity on behavioral and epigenetic outcomes. Front Psychiatry 4:78.

Mansuy IM, Mashoodh R, Champagne FA, 2013, Transgenerational inheritance in mammals. In Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact, Sweatt JD, Meaney MJ, Nestler EJ, Schahram A, eds., Elsevier.

Peña CL, Champagne FA, 2013, Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring. Behavioral Neuroscience 127(1):33-46.

Peña CJ, Neugut YD, Champagne FA, 2013, Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats. Endocrinology 154(11), 4340-51.

Wan M, Hejjas K, Ronai Z, Elek Z, Sasvari-Szekely M, Champagne FA, Miklósi A, Kubinyi E, 2013, DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs. Animal Genetics 44(6), 717-27.


Champagne FA, 2012, Interplay between social experiences and the genome: epigenetic consequences for behavior, Advances in Genetics 77:33-57.

Champagne FA & Curley JP, 2012, Genetics and epigenetics of parental care. In: The Evolution of Parental Care, Royle NJ, Smiseth PT, Kölliker M eds., Oxford University Press.

Curley JP, Jensen CL, Franks B & Champagne FA, 2012, Variation in maternal and anxiety-like behavior associated with discrete patterns of oxytocin and vasopressin 1a receptor density in the lateral septum. Hormones & Behavior 61: 454-461.

Franks B, Higgins ET & Champagne FA, 2012, Evidence for individual differences in regulatory focus in rats, Rattus norvegicus, Journal of Comparative Psychology126(4):347-54.

Gudsnuk KM & Champagne FA, 2012, Epigenetic influence of stress and the social environment. ILAR J 53 (3-4): 279-288.

Jensen CL & Champagne FA, 2012, Epigenetic and neurodevelopmental perspectives on variation in parenting behavior, Parenting: Science and Practice 12(2-3):202-211.

Jensen-Peña CL, Monk C, Champagne FA, 2012, Epigenetic effects of prenatal stress on 11ß-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain, PLoS ONE 7(6):e39791.

Liberman SA, Mashoodh R, Thompson RC, Dolinoy DC, Champagne FA, 2012, Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse, Ecology and Evolution 2(12): 3123–3131.

Mashoodh R, Franks B, Curley JP, Champagne FA, 2012, Paternal social enrichment effects on maternal behavior and offspring growth, Proceedings of the National Academy of Sciences USA 109 Suppl 2:17232-8.

Monk C, Spicer J & Champagne FA, 2012, Linking prenatal maternal adversity to developmental outcomes in infants: The role of epigenetic pathways,Development & Psychopathology 24(4):1361-76.

Roth TL & Champagne FA, 2012, Epigenetic pathways and the consequences of adversity and trauma. In Biological and Genetic Factors in Understanding Trauma, Psychopathology, and Violence, Spatz Widom C ed., Oxford University Press.

Swaney WT, Dubose BN, Curley JP, Champagne FA, 2012, Sexual experience affects reproductive behavior and preoptic androgen receptors in male mice, Hormones & Behavior 61: 472-478.

Wan M, Bolger N, Champagne FA, 2012, Human perception of fear in dogs varies according to experience with dogs. PLoS ONE 7(12), e51775.


Champagne FA, 2011, Maternal imprints and the origins of variation, Hormones & Behavior 60: 4-11.

Champagne FA & Curley JP, 2011, Epigenetic influence of the social environment, In Petronis A & Mill J (eds) Brain, Behavior & Epigenetics. Springer. pp 185-208

Champagne FA & Curley JP, 2011, Parental behavior and the perinatal programming of infant development, In Fink G, Pfaff DW & Levine JE (eds) Handbook of Neuroendocrinology. Elsevier.

Champagne FA & Rissman EF, 2011, Behavioral epigenetics: A new frontier in the study of hormones and behavior, Hormones and Behavior 59: 277-278.

Curley JP, Jensen CL, Mashoodh R & Champagne FA, 2011, Social influences on neurobiology and behavior: Epigenetic effects during development, Psychoneuroendocrinology 36: 352-371.

Curley JP, Mashoodh R & Champagne FA, 2011, Epigenetics and the origin of paternal effects, Hormones & Behavior 59: 306-314.

Danchin E, Charmantier A, Champagne FA, Mesoudi A, Pujol B & Blanchet S, 2011, Beyond DNA: integrating inclusive inheritance into an extended theory of evolution, Nature Reviews Genetics 12: 475-486.

Franks B, Curley JP & Champagne FA, 2011, Measuring variations in maternal behavior: Relevance for studies of mood and anxiety, In Gould T. (ed) Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests Vol 2. Springer - pp 209-223

Gudsnuk KM & Champagne FA, 2011, Epigenetic effects of early developmental experiences, Clinics in Perinatology 38:703-17.

Kundakovic M & Champagne FA, 2011, Epigenetic Perspective on the Developmental Effects of Bisphenol A, Brain, Behavior & Immunity 25: 1084-93.


Champagne FA, 2010, Early adversity and developmental outcomes : Interaction between genetics, epigenetics, and social experiences across the life span, Perspectives on Psychological Science 5: 564-574.

Champagne FA, 2010, Epigenetic influence of social experiences across the lifespan, Developmental Psychobiology 52: 299-311.

Champagne FA, 2010, Epigenetic perspectives on development: Evolving insights on the origins of variation, Developmental Psychobiology 52: e1-e3.

Champagne FA & Curley JP, 2010, Maternal care as a modulating influence on infant development, p323-341, In Blumberg MS, Freeman JH & Robinson SR. (eds) Developmental and Comparative Neuroscience: Epigenetics, Evolution & Behavior. Oxford University Press: Oxford, UK.

Curley JP, Mashoodh R & Champagne FA, 2010, Transgenerational Epigenetics, In Tollefsbol TO. (ed) Handbook of epigenetics: the new molecular and medical genetics. Academic Press: Boston, USA.

Curley JP, Rock V, Moynihan AM, Bateson P, Keverne EB & Champagne FA, 2010, Developmental shifts in the behavioral phenotypes of inbred mice: The role of postnatal and juvenile social experiences, Behavior Genetics 40: 220-232.


Alter MD, Gilani AI, Champagne FA, Curley JP, Turner JB. & Hen R, 2009, Paternal transmission of complex phenotypes in inbred mice. Biological Psychiatry 66: 1061-6.

Champagne FA, 2009, Nurturing nature: social experiences and the brain, Journal of Neuroendocrinology 21: 867-868.

Champagne FA & Curley JP, 2009, Epigenetic mechanisms mediating the long-term effects of maternal care on development, Neuroscience & Biobehavioral Reviews 33: 593-600

Champagne FA & Curley JP, 2009, The trans-generational influence of maternal care on offspring gene expression and behavior in rodents, In Maestripieri D & Matteo JM. (eds) The role of maternal effects in mammalian evolution and adaptation. Chicago University Press: Chicago, USA.

Champagne FA & Mashoodh R, 2009, Genes in context: Gene–environment interplay and the origins of individual differences in behavior, Current Directions in Psychological Science 18: 127-131.

Champagne FA, Curley JP, Swaney WT, Hasen N & Keverne EB, 2009, Paternal influence on female behavior: The role of Peg3 in exploration, olfaction and neuroendocrine regulation of maternal behavior of female mice, Behav Neuro 123: 469-480.

Curley JP, Jordan E, Swaney WT, Izraelit A, Kammel S & Champagne FA, 2009, The meaning of weaning: Influence of the weaning period on behavioral development in mice, Developmental Neuroscience 31: 318-331.

Curley JP, Davidson S, Bateson P, & Champagne FA, 2009, Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice, Frontiers in Behavioral Neuroscience 3(25): 1-14.

Fagiolini M, Jensen CL & Champagne FA, 2009, Epigenetic influences on brain development and plasticity, Current Opinion in Neurobiology 19: 1-6.

Mann JJ et al. 2009, Candidate endophenotypes for genetic studies of suicidal behavior, Biological Psychiatry 65: 556-563.

Wan M, Kubinyi E, Miklosi A, & Champagne F, 2009, A cross-cultural comparison of reports by German Shepherd owners in Hungary and the United States of America, Applied Animal Behaviour Science 121: 206-213.


Cameron NM, Shahrokh D, Del Corpo A, Dhir SK, Szyf M, Champagne FA & Meaney MJ, 2008, Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care, Journal of Neuroendocrinology 20: 795-801.

Champagne FA, 2008, Maternal influence on offspring reproductive behavior: Implications for transgenerational effects, p305-318, In R. Bridges (ed). "Neurobiology of the Parental Brain", Academic Press.

Champagne FA, 2008, Epigenetic mechanisms and the transgenerational effects of maternal care, Frontiers in Neuroendocrinology 29: 386-397

Champagne FA & Curley JP, 2008, Maternal regulation of ERa methylation, Current Opinion in Pharmacology 8: 735-739.

Curley JP, Champagne FA, Bateson P & Keverne EB, 2008, Transgenerational effects of impaired maternal care on behaviour of offspring and grandoffspring. Animal Behaviour. 75: 1551-1561.

Swaney WT, Curley JP, Champagne FA & Keverne EB, 2008, The paternally expressed gene Peg3 regulates sexual experience-dependent preferences for estrous odors, Behav Neuro 122: 963-973.


Champagne FA & Meaney MJ, 2007, Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty, Behav. Neuro 121: 1353-1363.

Champagne FA, Curley JP, Bateson PPG & Keverne EB, 2007, Natural variations in postpartum maternal care in inbred and outbred mice. Physiology & Behavior 91: 325-334.

Swaney WT, Curley JP, Champagne FA & Keverne EB, 2007, Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice, PNAS 104: 6084-6089.


Champagne FA & Meaney MJ, 2006, Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model. Biol Psychiatry. 59:1227-35

Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf M, & Meaney MJ, 2006, Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology. 147:2909-15


Cameron NM, Champagne FA, Parent C, Fish EW, Ozaki-Kuroda K & Meaney MJ, 2005, The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care. Neuroscience & Biobehavioral Reviews. 29:843-65.

Champagne FA & Curley JP, 2005, How social experiences influence the brain, Current Opinion in Neurobiology. 15(6): 704-709

Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DE, & Nestler EJ, 2005, Epigenetic mechanisms and gene networks in the nervous system. Journal of Neuroscience. 25:10379-89.

Parent C, Zhang TY, Caldji C, Bagot R, Champagne FA, Pruessner J & Meaney MJ, 2005, Maternal care and individual differences in defensive responses, Current Directions in Psychological Science 14: 229-233.

St-Hilaire A, Holowka D, Cunningham H, Champagne F, Pukall M & King S, 2005, Explaining variation in the premorbid adjustment of schizophrenia patients: the role of season of birth and family history, Schiz Res. 73:39-48.

Szyf M, Weaver IC, Champagne FA, Diorio J, & Meaney MJ, 2005, Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Frontiers in Neuroendocrinology. 26:139-62.

Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, & Szyf M, 2005, Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. Journal of Neuroscience. 25:11045-54.


Champagne FA, Chretien P, Stevenson CW, Zhang TY, Gratton A & Meaney MJ, 2004,Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat, Journal of Neuroscience. 24:4113-23.

Pruessner JC, Champagne F, Meaney MJ & Dagher A, 2004 Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using 11C raclopride, Journal of Neuroscience. 24:2825-31.

Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M & Meaney MJ, 2004, Epigenetic programming by maternal behavior, Nature Neuroscience. 7:847-54


Champagne FA, Francis DD, Mar A, & Meaney MJ, 2003, Variations in maternal care in the rat as a mediating influence for the effects of environment on development, Physiology & Behavior. 79:359-71.

Champagne FA, Weaver IC, Diorio J, Sharma S & Meaney MJ, 2003, Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area, Endocrinology. 144:4720-4